There is something new to talk about this flu season.
The U.S. Food and Drug Administration has approved MFLUSIVA, the first mRNA-based seasonal flu vaccine, for adults ages 50 and older. If “mRNA” sounds familiar, that is because the same type of technology has been used in COVID-19 vaccines.
Now, it is making its way into seasonal flu protection. So, what does that mean for older adults and their families? Let’s break it down.
What Is the New mRNA Flu Vaccine?
MFLUSIVA is a trivalent vaccine designed to protect against the influenza A and B strains represented in the vaccine. Instead of containing influenza viruses, it uses mRNA to give the body temporary instructions that help the immune system recognize and respond to the flu.
According to the FDA, MFLUSIVA cannot cause influenza because it does not contain the influenza virus.
The vaccine is approved for adults ages 50 and older. For adults 65 and older, it received accelerated approval based on immune-response data. Continued approval for this age group may depend on additional research confirming its clinical benefits.
How Effective Is MFLUSIVA?
In a Phase 3 trial involving approximately 40,000 adults, MFLUSIVA was 26.6% more effective than a standard-dose flu vaccine at preventing influenza among adults ages 50 to 64. The reported relative effectiveness was 27.4% higher among adults 65 and older.
That does not mean the vaccine prevents every case of the flu. No flu vaccine can guarantee complete protection. It does, however, introduce another potentially important option as healthcare providers prepare for the 2026–27 flu season.
Does It Replace the High-Dose Flu Shot for Seniors?
Not right now.
FDA approval means the vaccine is authorized for use, but approval and public-health recommendations are not the same thing. As of August 14, 2026, final CDC recommendations for the 2026–27 flu season had not yet been published. Availability and insurance coverage for MFLUSIVA were also still being finalized.
Current CDC guidance gives preference to three established options for adults ages 65 and older:
- High-dose inactivated flu vaccine
- Adjuvanted inactivated flu vaccine
- Recombinant flu vaccine
If none of these preferred vaccines is available when it is time to get vaccinated, the CDC advises receiving another age-appropriate flu vaccine instead of waiting.
When Should Seniors Get Their Flu Shot?
For most older adults, September or October remains the recommended vaccination window.
Getting vaccinated too early may mean protection begins to decrease before flu activity peaks. Waiting too long, however, could leave someone unprotected as flu begins circulating.
Health needs can vary, so families should speak with a trusted healthcare provider about the best vaccine and timing for their loved one.
What About Medicare Coverage?
Medicare Part B covers one seasonal flu vaccine, usually once each flu season. People with Medicare generally pay nothing when the healthcare provider accepts Medicare assignment.
Because MFLUSIVA is new, families should confirm its availability and coverage with their healthcare provider, pharmacy and insurance plan before scheduling an appointment.
Five Questions Families Can Ask
When scheduling a flu shot, consider asking:
- Which flu vaccine is recommended for my age and medical history?
- Is MFLUSIVA available at this location?
- Is the new vaccine covered by my insurance?
- Would a high-dose, adjuvanted or recombinant vaccine be a better option?
- Can I safely receive my flu shot with other recommended vaccines?
At Empire Care Centers, we know that new health information can bring plenty of questions. That is completely normal. What matters most is getting clear guidance, making an informed decision and taking steps to protect the people we love.
The technology may be new, but the goal is one we all know well: a healthier flu season for residents, families and communities.
This article is for general educational purposes and is not a substitute for individualized medical advice. Speak with a qualified healthcare provider before making vaccination decisions.
Have Questions About Senior Care?
Our compassionate care professionals are here to help you navigate the next steps with clarity and confidence. Contact Empire Care Centers today to learn more about our services and find the right care center for your family.
Sources
- U.S. Food and Drug Administration. “MFLUSIVA.” Updated August 7, 2026.
- U.S. Food and Drug Administration. “MFLUSIVA: Prescribing Information.” 2026–2027 Formula. Initial U.S. approval: 2026.
- Centers for Disease Control and Prevention. “ACIP Recommendations Summary: Influenza.” Updated June 10, 2026.
- National Council on Aging. “What Older Adults Need to Know During Flu Season.” Updated August 14, 2026.
- National Council on Aging. “When Should I Get My Flu Shot? A Guide for Older Adults.” Updated August 14, 2026.
- Medicare.gov. “Flu Vaccines.” Centers for Medicare & Medicaid Services.
